![]() ![]() ![]() 6 In the Toru example, the resolution is accomplished by dynamic resolution of planar-chiral organolithium enantiomers by the bisoxazoline ligand, followed by precipitation of homochiral aggregates (an asymmetric transformation of the second kind). Toru reported a catalytic dynamic resolution (CDR, Scheme 2), which is driven by the well-known phenomenon of crystallization-induced asymmetric transformation. Thus, a variation of a dynamic resolution using a catalytic amount of L* is desirable. A disadvantage of a DTR can arise if the electrophile used to react with the organolithium is also reactive toward, and consumes, the chiral ligand, L*. A dynamic thermodynamic resolution, or DTR, using stoichiometric chiral ligand, L*.ĭynamic resolutions hold significant potential, since they obviate the need for an enantioselective deprotonation or an asymmetric synthesis of an enantioenriched precursor stannane. ![]()
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